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Changes to Mycobacterium paratuberculosis site.
September 2nd, 1998:- Added some cross links to Mihailo's page about the causes of Crohn's disease, which includes a page about Mycobacterium paratuberculosis. Most interesting is his page about the transmissibility of Crohn's disease.
August 11th, 1998:- Added a link to an article from BBC television news. The British Government comes clean about Mycobacterium paratuberculosis in milk. Read about it here:- Health scare over milk.
August 8th, 1998:- Added a list of the research papers which are available in full-text on this web site.
July 30th, 1998:- Added the full text of a paper which discusses the use of clarithromycin and rifabutin in combination against Mycobacterium avium. Remember that the correct classification of Mycobacterium paratuberculosis is actually Mycobacterium avium subspecies paratuberculosis. This paper is referred to by Hermon-Taylor in his paper Two-year outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics. Full text:- Effects of Clarithromycin and Rifabutin Alone and in Combination on Intracellular and Extracellular Replication of Mycobacterium avium.
July 30th, 1998:- Added the full text of a paper which discusses the use of the macrolide antibiotic clarithromycin in the treatment of Mycobacterium avium infections. Remember that the correct classification of Mycobacterium paratuberculosis is actually Mycobacterium avium subspecies paratuberculosis. This paper explains why anti-tuberculosis antibiotic treatment is no good for Crohn's disease:- anti-tuberculosis drugs have no effect against Mycobacterium avium. Only the macrolide antibiotics Clarithromycin and Azithromycin have enough effect against Mycobacterium avium to be of any use. Full text:- Clarithromycin against Mycobacterium avium complex infections.
July 30th, 1998:- Added the full text of the latest epidemiology research from Olmsted County, Minnesota (home of the Mayo Clinic). It makes for scary reading. Full text:- Crohn's Disease in Olmsted County, Minnesota, 1940-1993: Incidence, Prevalence, and Survival.
July 30th, 1998:- Added the full text of a paper which discusses the possibility of vaccination for Crohn's disease as an addition to antibiotic treatment. Full text:- Is immunotherapy with Mycobacterium vaccae appropriate to Crohn's disease?.
July 30th, 1998:- Added the full text the first research paper ever to suggest that Crohn's could be treated with antibodies to Tumor Necrosis Factor-alpha (e.g. Avakine, Infliximab). Of course, their proposal is based on the theory that mycobacteria play a role in causing Crohn's disease. Full text :- Immunotherapeutical approaches to Crohn's disease in view of a possible pathogenic role of Mycobacterial antigens.
July 30th, 1998:- Updated page The Financial cost of Crohn's disease to reflect the latest figures from the USA. Based on current estimates from the United States, medical treatment for Crohn's disease across the world costs at least US$12 billion per year. And that's just medical costs! It doesn't count social welfare support, lost productivity, or the enormous cost in human suffering.
June 11th, 1998:- Complete re-organization of the site.
February 10th, 1998:- STOP PRESS! Added vitally important new research which proves that M paratuberculosis causes disease in human beings. The paper describes the case of a young boy who developed "Cervical Lymphadenitis" (a lump in the neck) from M paratuberculosis, and went on to develop Crohn's disease five years later. Full text available:- "Mycobacterium paratuberculosis Cervical Lymphadenitis followed five years later by terminal ileitis similar to Crohn's Disease."
October 29th, 1997:- Added missing "Materials and Methods" and "References" sections to "IS900 PCR To Detect Mycobacterium Paratuberculosis in Retail Supplies of Whole Pasteurized Cows' Milk in England and Wales."
October 10th, 1997:- Added full text of paper "Pasteurisation of Mycobacterium paratuberculosis in whole milk"
October 10th, 1997:- Added full text of Chiodini paper "Crohn's disease and the mycobacterioses: a review and comparison of two disease entities."
September 21st, 1997:- Added a page of Frequently Asked Questions.
August 15th, 1997:- Added link to University of Wisconsin research into survival of Mycobacterium paratuberculosis in cheese.
July 3rd, 1997:- Added the paper "Johne's Disease - The international perspective".
June 30th, 1997:- Added missing figures from paper "Two year outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics".
June 15th, 1997:- Added list of UHT milk available in different countries.
May 25th, 1997:- Added information about survival of different bacteria in HTST milk.
April 30th, 1997:- Added a links page. However, comprehensive information sites about Mycobacterium paratuberculosis and Crohn's disease are still lacking.
April 10th, 1997:- Added a large section on the epidemiology of Crohn's disease. This contains some important information, including strong evidence that supports the involvement of Mycobacterium paratuberculosis in the disease.
Summary of main points