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Mycobacterium paratuberculosis Cervical Lymphadenitis followed five years later by terminal ileitis similar to Crohn's Disease.
This paper was published in the British Medical Journal on February 7th 1998. This paper is a breakthrough in paratuberculosis research, because it describes the worlds first documented case of disease in a human being caused by Mycobacterium paratuberculosis. The summary of the paper contains all of the salient points, so I reproduce that here.
Full text available: Mycobacterium paratuberculosis Cervical Lymphadenitis followed five years later by terminal ileitis similar to Crohn's Disease.
In September 1988 a seven year old boy living in a village outside Cambridge, developed non-tuberculous mycobacterial cervical lymphadenitis. The nodes were removed and later shown to contain abundant Mycobacterium paratuberculosis. This pathogen causes chronic inflammation of the intestine ranging from a pluribacillary 'lepromatous' type to a paucimicrobial 'tuberculoid' type, in many species of animals including primates. Five years later he presented with chronic inflammation of the intestine affecting the terminal ileum and ascending colon, similar to Crohn's disease. This resolved on prolonged treatment with a combination of rifabutin and clarithromycin, leaving a healed ileal scar which required excision. As with M. bovis earlier this century, infection with M. paratuberculosis was probably acquired by the consumption of milk contaminated with these robust versatile organisms.
Important points to note.
Biopsy studies of Crohn's Disease Patients.
Two-year outcomes analysis of Crohn's Disease treated with rifabutin and macrolide antibiotics