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Title: Occurrence, in Crohn's disease, of antibodies directed against a species-specific recombinant polypeptide of Mycobacterium paratuberculosis.
Title Abreviation: Clin Diagn Lab Immunol Date of Pub: 1994 Mar
Author: Vannuffel P; Dieterich C; Naerhuyzen B; Gilot P; Coene M; Fiasse R; Cocito C;
Issue/Part/Supplement: 2 Volume Issue: 1 Pagination: 241-3
MESH Headings: Antibodies, Bacterial (*CH); Antigens, Bacterial (*IM); Crohn Disease (*IM/MI); Human; Mycobacterium paratuberculosis (*IM); Peptides (*IM); Recombinant Proteins (IM); Species Specificity; -RN-;
Journal Title Code: CB7 Publication Type: JOURNAL ARTICLE
Date of Entry: 960116NEntry Month: 9603
Country: UNITED STATES Index Priority: 2
Language: Eng Unique Identifier: 96050815
Unique Identifier: 96050815 ISSN: 1071-412X
Abstract: Sera from patients with Crohn's disease and control were analyzed by an enzyme-linked immunosorbent assay based on the Mycobacterium paratuberculosis-specific recombinant polypeptide a362. Anti-a362 immunoglobulin G (IgG) (P < 0.05) and IgA (P < 0.001) titers were higher in patients with Crohn's disease than in controls. A monomodal Gaussian distribution of anti-a362 IgA levels were found for controls, and a bimodal distribution was found for patients with Crohn's disease. An M. paratuberculosis etiology is suggested for the 36% of patients with Crohn's disease who had an anti-a362 IgA level higher than that of controls.
Abstract By: Author
Address: Microbiology and Genetics Unit, University of Louvain, Brussels, Belgium.