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Title: Possible role of mycobacteria in inflammatory bowel disease. II. Mycobacterial antibodies in Crohn's disease.
Title Abreviation: Dig Dis Sci Date of Pub: 1984 Dec
Author: Thayer WR Jr; Coutu JA; Chiodini RJ; Van Kruiningen HJ; Merkal RS;
Issue/Part/Supplement: 12 Volume Issue: 29 Pagination: 1080-5
MESH Headings: Adolescence; Adult; Aged; Animal; Antibodies, Bacterial (*AN); Cattle; Child; Colitis, Ulcerative (IM); Comparative Study; Crohn Disease (*IM); Cross Reactions; Enzyme-Linked Immunosorbent Assay; Female; Human; Male; Middle Age; Mycobacterium (*IM); Mycobacterium tuberculosis (IM); Mycobacterium, Atypical (IM); Paratuberculosis (IM/MI); Support, Non-U.S. Gov't; Tuberculosis (IM); -RN-;
Journal Title Code: EAD Publication Type: JOURNAL ARTICLE
Date of Entry: 850118NEntry Month: 8503
Country: UNITED STATES Index Priority: 1
Language: Eng Unique Identifier: 85050686
Unique Identifier: 85050686 ISSN: 0163-2116
Abstract: An unclassified Mycobacterium species has been isolated from two patients with Crohn's disease (CD). Antibodies to the unclassified mycobacteria cross-reacted with Mycobacterium paratuberculosis. Because of this cross-reactivity, an enzyme-linked immunosorbent assay (ELISA) was used to examine the sera of inflammatory bowel disease (IBD) patients, both CD (N = 56), and ulcerative colitis (UC) (N = 34), for antibodies to M. paratuberculosis, Mycobacterium kansasii, and Mycobacterium tuberculosis. Controls consisted of healthy, PPD-negative individuals (N = 67), and from PPD-positive patients (N = 41). Eighteen resected CD patients were also examined. CD patients had a statistically significant increase in antibody titer (P = 0.0003) to M. paratuberculosis compared to healthy controls. Although patients with positive PPD had elevated titers to this organism, the positive response of CD patients was not related to PPD responsiveness, area of involvement in the gut, nor to activity of the disease process.
Abstract By: Author