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Title: Experimental disease in young chickens induced by a Mycobacterium paratuberculosis isolate from a patient with Crohn's disease.
Title Abreviation: Can J Vet Res Date of Pub: 1991 Apr
Author: Van Kruiningen HJ; Ruiz B; Gumprecht L;
Issue/Part/Supplement: 2 Volume Issue: 55 Pagination: 199-202
MESH Headings: Animal; Bursa of Fabricius (PA); Cecum (PA); Chickens (*); Crohn Disease (*MI); Gastrointestinal System (PA); Granuloma (MI/PA/VE); Human; Lung Diseases (MI/PA/VE); Lymphoid Tissue (PA); Mycobacterium (IP/*PY); Paratuberculosis (*MI/PA); Poultry Diseases (*MI/PA); Specific Pathogen-Free Organisms; Support, U.S. Gov't, P.H.S.; -AA-;
Journal Title Code: CKL Publication Type: JOURNAL ARTICLE
Date of Entry: 911009NEntry Month: 9112
Country: CANADA Index Priority: 2
Language: Eng Unique Identifier: 91356433
Unique Identifier: 91356433 ISSN: 0830-9000
Abstract: The susceptibility of young chickens to infection with an isolate of Mycobacterium paratuberculosis which had been recovered from diseased tissues of a patient with Crohn's disease was determined. Two-week-old Leghorn-Cochin chicks were inoculated with strain Linda. Six birds received 10(7) organisms orally, six intraperitoneally, and five intracardially. Six uninoculated birds served as contact controls. Birds from each group were necropsied at two-week intervals. Focal granulomatous lesions occurred in two of six chickens which were inoculated orally, in six of six inoculated intraperitoneally, in three of five inoculated intracardially, but in none of six controls. Of the 11 birds with lesions, acid-fast bacilli were demonstrated in five. Immunoperoxidase reactivity paralleled the presence of acid-fast bacilli.
Abstract By: Author
Address: Department of Pathobiology, University of Connecticut, Storrs 06269.